here's what you need to know.Rapamycin for dogs
It just may help your dog live longer.
Rapamycin for dogs. like yours.
Rapamycin for Dogs– Here’s How to Get It.
We hear it all the time — “where can I buy rapamycin for my dog?” or “how do I get rapamycin for my dog?”. The answer is simple. Right here at NaturalPet.Health.
Rapamycin is a prescription drug, and so we are happy to send it to you guys after…
- We receive a prescription from your veterinarian, or…
- We do a consultation on your pet here on the Central Coast of CA. There’s more info down below on our specialized consults. Hey, come on out– the weather’s great!! Or…
- You send records that tell us that your dog has been diagnosed with terminal cancer, in which case we will prescribe rapa for compassionate use.
We have limited quantities of 99% pure rapamycin in veggie capsules containing
- 0.5 mg for pets of about10#,
- 1.0 mg for dogs of about 20#, and
- 3 mg for dogs of about 60#
In stock …and ready to ship your way.
Your cost is $72 for 12 pills, plus a little for shipping.
Why 12 pills? Because rapamycin is given 3x a week, so 12 pills translates into a one month supply for most dogs.
Aztec's mom says...
Before rapamycin, Aztec was very lethargic and slept for most of the day. Now he can run after Frisbees, he steals things from my purse like before, and he is playing with his old toys.
I am SO grateful to Dr. Kevin... and rapamycin!!
Noodles' Dad says...
...I honestly believe that Dr. Kevin added a year to Noodles' life.
It was the best investment we could have made for our best friend....
Tex's dad says....
...Even at his age he is still very happy and engaged. His last blood work looked really great.
I feel the rapamycin greatly slowed down the degeneration in his spine.
Rapamycin for Dogs– Here’s the Deal.
Rapamycin EXTENDS LIFESPAN in every organism studied to date, from yeast to insects to marmosets. Yes, studies in humans have started 🙂
Rapamycin has also been proven to….
– REDUCE CANCER INCIDENCE (Anisimov et al. 2011),
– IMPROVE IMMUNE FUNCTION (Chen et al. 2009)
here’s what is really cool.
Rapamycin for Old Dogs
The benefits of beginning rapamycin therapy in old age appear comparable to the benefits of rapamycin given at a younger age, which is a great thing for us lovers of older dogs. (Harrison et al. 2009).
What’s this mean? IT’S NEVER TOO LATE TO SEE A POTENTIAL BENEFIT FOR OUR OLD DOGS.
Rapamycin To Help Dogs Live Longer–The Excitement
- Rapamycin significantly improved heart function—in particular, left ventricular function during the 10 week study, and that the improvement was greatest in those patients with more severe heart disease. According to the authors, these results suggest that rapamycin use in older dogs can actually reverse age-related declines in heart function. Now that’s a statement you don’t hear every day.
- Rapamycin created no significant laboratory changes at doses of either 0.05 or 0.1 mg per kg doses given 3x a week. What this means is that there were no apparent adverse effects during the 10 week study period.
- 70% of the owners whose dogs received the higher 0.1 mg/kg rapamycin dose felt that their dogs were more active while on rapamycin, as did 40% of those whose dogs received the lower 0.05 mg/kg dose. In fairness, about 25% of the owners who gave their pets a placebo reported the same thing, but still…
- Similarly, 20%-40% of owners felt their dogs were more affectionate while being given rapamycin. The authors suggest that this could be due to the anti-inflammatory effects of rapamycin helping to reduce pain in arthritic pets.
Thank you, Dr. Kaeberlein and friends!!
Rapamycin for Dogs With Cancer
Rapamycin for Dogs — The Questions.
There are four very important questions about rapamycin therapy for dogs that we don’t have the answers to at this time:
- The optimal dose: are rapamycin’s benefits dose-dependent, so that the higher the dose the more benefits? Or is there a dose beyond which no additional benefits are seen?
- The optimal duration: how many doses do our dogs need for optimal benefit?
- How long do the benefits of rapamycin last, and can this be altered with dosage or duration of therapy?
- What are the longer term risks and side effects of rapamycin therapy?
Lest we forget, rapamycin is a potent immune suppressant. In addition to impairing our ability to fight infections, high dose therapy in humans can create oral inflammation, high blood sugar, changes in lipid profiles, low platelets, and impaired wound healing.
The good news is that the Kaeberlein study, above, showed no evidence of these issues, but long term studies are ongoing.
I’m using it on my own dog. I can’t say much else.
Rapamycin for Dogs — Early Answers
THE DOSING OF RAPAMYCIN FOR DOGS:
- The Kaeberlein study used 0.05 mg/kg and 0.1 mg/kg given orally 3x a week appeared safe and also improved cardiac function. From a practical standpoint, this dose translates to 1 mg per 22-44 lbs body weight.
THE DURATION OF RAPAMYCIN TREATMENT FOR DOGS
- Even one dose or short term therapy may improve our pets’ cardiac function and healthspan
- Studies have shown that rapamycin binds to its receptor mTOR to inhibit two different protein complexes: the quick-forming mTORC1 and the more slowly-forming mTORC2.
In the past few years, it has been generally accepted that the BENEFITS of increased health and lifespan are due to inhibiting the quick-forming mTORC1, and that most of the NEGATIVE side effects are due to inhibiting the more slowly-forming mTORC2.
What’s this mean to us? This suggests that single- or short term dosing with rapamycin, which inhibits mTORC1, would offer more benefits and less risk than chronic dosing of rapamycin and resultant inhibition of mTORC2
iNTERESTED IN rapamycin for your dog??